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One of the earliest was the Padua botanical garden.

These gardens facilitated the academic study of plants.

1248) wrote on botany in a systematic and scientific manner.

In the mid-16th century, "botanical gardens" were founded in a number of Italian universities – the Padua botanical garden in 1545 is usually considered to be the first which is still in its original location.

Lectures were given about the plants grown in the gardens and their medical uses demonstrated.

Botanical gardens came much later to northern Europe; the first in England was the University of Oxford Botanic Garden in 1621.

Research topics include the study of plant structure, growth and differentiation, reproduction, biochemistry and primary metabolism, chemical products, development, diseases, evolutionary relationships, systematics, and plant taxonomy.

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Bock created his own system of plant classification.Important contributions from the medieval Muslim world include Ibn Wahshiyya's Nabatean Agriculture, Abū Ḥanīfa Dīnawarī's (828–896) the Book of Plants, and Ibn Bassal's The Classification of Soils.In the early 13th century, Abu al-Abbas al-Nabati, and Ibn al-Baitar (d.1611) published herbals covering the medicinal uses of plants.Naturalist Ulisse Aldrovandi (1522–1605) was considered the father of natural history, which included the study of plants.